Brain modular connectivity interactions can predict proactive inhibition in smokers when facing smoking cues.

Proactive inhibition is a critical ability for smokers who seek to moderate or quit smoking. It allows them to pre-emptively refrain from seeking and using nicotine products, especially when facing salient smoking cues in daily life. Nevertheless, there is limited knowledge on the impact of salient cues on behavioural and neural aspects of proactive inhibition, especially in smokers with nicotine withdrawal. Here, we seek to bridge this gap. To this end, we recruited 26 smokers to complete a stop-signal anticipant task (SSAT) in two separate sessions: once in the neutral cue condition and once in the smoking cue condition. We used graph-based modularity analysis to identify the modular structures of proactive inhibition-related network during the SSAT and further investigated how the interactions within and between these modules could be modulated by different proactive inhibition demands and salient smoking cues. Findings pointed to three stable brain modules involved in the dynamical processes of proactive inhibition: the sensorimotor network (SMN), cognitive control network (CCN) and default-mode network (DMN). With the increase in demands, functional connectivity increased within the SMN, CCN and between SMN-CCN and decreased within the DMN and between SMN-DMN and CCN-DMN. Salient smoking cues disturbed the effective dynamic interactions of brain modules. The profiles for those functional interactions successfully predicted the behavioural performance of proactive inhibition in abstinent smokers. These findings advance our understanding of the neural mechanisms of proactive inhibition from a large-scale network perspective. They can shed light on developing specific interventions for abstinent smokers.

Imbalanced weighting of proactive and reactive control as a marker of risk-taking propensity.

According to the dual mechanisms of control (DMC), reactive and proactive control are involved in adjusting behaviors when maladapted to the environment. However, both contextual and inter-individual factors increase the weight of one control mechanism over the other, by influencing their cognitive costs. According to one of the DMC postulates, limited reactive control capacities should be counterbalanced by greater proactive control to ensure control efficiency. Moreover, as the flexible weighting between reactive and proactive control is key for adaptive behaviors, we expected that maladaptive behaviors, such as risk-taking, would be characterized by an absence of such counterbalance. However, to our knowledge, no studies have yet investigated this postulate. In the current study, we analyzed the performances of 176 participants on two reaction time tasks (Simon and Stop Signal tasks) and a risk-taking assessment (Balloon Analog Risk Taking, BART). The post-error slowing in the Simon task was used to reflect the spontaneous individuals' tendency to proactively adjust behaviors after an error. The Stop Signal Reaction Time was used to assess reactive inhibition capacities and the duration of the button press in the BART was used as an index of risk-taking propensity. Results showed that poorer reactive inhibition capacities predicted greater proactive adjustments after an error. Furthermore, the higher the risk-taking propensity, the less reactive inhibition capacities predicted proactive behavioral adjustments. The reported results suggest that higher risk-taking is associated with a smaller weighting of proactive control in response to limited reactive inhibition capacities. These findings highlight the importance of considering the imbalanced weighting of reactive and proactive control in the analysis of risk-taking, and in a broader sense, maladaptive behaviors.

The contribution of episodic long-term memory to working memory for bindings.

The present experiments support two conclusions about the capacity limit of working memory (WM). First, they provide evidence for the Binding Hypothesis, WM capacity is limited by interference between bindings but not items. Second, they show that episodic LTM contributes substantially to binding memory when the capacity of WM is stretched to the limit by larger set sizes. We tested immediate memory for sets of word-picture pairs. With increasing set size, memory for bindings declined more precipitously than memory for items, as predicted from the binding hypothesis. Yet, at higher set sizes performance was more stable than expected from a capacity limited memory, suggesting a contribution of episodic long-term memory (LTM) to circumvent the WM capacity limit. In support of that hypothesis, we show a double dissociation of contributions of WM and episodic LTM to binding memory: Performance at set sizes larger than 3 was specifically affected by proactive interference - but were immune to influences from a distractor-filled delay. In contrast, performance at set size 2 was unaffected by proactive interference but harmed by a distractor-filled delay.

Sex Does Not Sell: The Effect of Sexual Content on Advertisement Effectiveness and Interference with Memory for Program Information.

Does increasing the sexual content of advertisements lead, though memory processes, to greater sales? By employing a between-participants design, we aimed to explore how sexual advertising affects explicit and implicit memory, and whether it impairs memory for information preceding the commercials (retroactive interference) or following the commercials (proactive interference). We randomly assigned 182 young participants in the UK to one of two groups who watched the same TV program containing an advertisement break during which either sexual or nonsexual advertisements were shown, while brands were held constant across conditions. Participants were then tested on their explicit and implicit memory for both the advertising content and program information. Results revealed that implicit memory was better for nonsexual than for sexual advertisements. Unexpectedly, there was no group difference in participants' explicit memory for the advertisements. Further, sexual advertising resulted in retroactive interference with program information, whereas proactive memory for program information was not impaired. We acknowledge various study limitations and discuss proposals for future research.

Differential effects of proactive and retroactive interference in value-directed remembering for younger and older adults.

We are often presented with more information than we can remember, and we must selectively focus on the most valuable information to maximize memory utility. Most tests of value-based memory involve encoding and then being tested on a list of recently studied information. Thus, people are focused on memory for the current list and are encouraged to forget information from earlier lists. However, prior learning can influence later memory, in both interfering and beneficial ways, and there may be age-related differences in how younger and older adults are influenced by the costs and benefits of prior learning and interference. In the present study, we presented younger and older adults with words paired with point values to remember for a later test but rather than asking participants to only recall words from the just-studied list, participants were asked to recall all studied words on each recall test. Results revealed that younger adults were more likely to recall words from previous lists than older adults, indicating that older adults were more susceptible to retroactive interference. Moreover, although selectivity is often preserved in older adults when study-test cycles are independent, a buildup of proactive interference arising from previously studied words reduced memory selectivity in older adults. Thus, when presented with more information than one can remember, younger adults are better at combating interference and recalling valuable information, while older adults may engage in selective forgetting of prior lists to enhance a "present-focused" form of memory, possibly as a result of impaired inhibitory control. (PsycInfo Database Record (c) 2022 APA, all rights reserved).

TMS reveals distinct patterns of proactive and reactive inhibition in motor system activity.

Response inhibition is our ability to suppress or cancel actions when required. Deficits in response inhibition are linked with a range of psychopathological disorders including addiction and OCD. Studies on response inhibition have largely focused on reactive inhibition-stopping an action when explicitly cued. Less work has examined proactive inhibition-preparation to stop ahead of time. In the current experiment, we studied both reactive and proactive inhibition by adopting a two-step continuous performance task (e.g., "AX"-CPT) often used to study cognitive control. By combining a dot pattern expectancy (DPX) version of this task with transcranial magnetic stimulation (TMS), we mapped changes in reactive and proactive inhibition within the motor system. Measured using motor-evoked potentials, we found modulation of corticospinal excitability at critical timepoints during the DPX when participants were preparing in advance to inhibit a response (at step 1: during the cue) and while inhibiting a response (at step 2: during the probe). Notably, motor system activity during early timepoints was predicted by a behavioural index of proactive capacity and could predict whether participants would later successfully inhibit their response. Our findings demonstrate that combining TMS with a two-step CPT such as the DPX can be useful for studying reactive and proactive inhibition, and reveal that successful inhibition is determined earlier than previously thought.

Early response competition over the motor cortex underlies proactive control of error correction.

Response inhibition is a fundamental brain function that must be flexible enough to incorporate proactive goal-directed demands, along with reactive, automatic and well consolidated behaviors. However, whether proactive inhibitory processes can be explained by response competition, rather than by active top-down inhibitory control, remains still unclear. Using a modified version of the Eriksen flanker task, we examined the behavioral and electrophysiological correlates elicited by manipulating the degree of inhibitory control in a task that involved the fast amendment of errors. We observed that restraining or encouraging the correction of errors did not affect the behavioral and neural correlates associated to reactive inhibition. We rather found that an early, sustained and bilateral activation, of both the correct and the incorrect response, was required for an effective proactive inhibitory control. Selective unilateral patterns of response preparation were instead associated with defective response suppression. Our results provide behavioral and electrophysiological evidence of a simultaneous dual pre-activation of two motor commands, likely underlying a global operating mechanism suggesting competition or lateral inhibition to govern the amendment of errors. These findings are consistent with the response inhibitory processes already observed in speed-accuracy tradeoff studies, and hint at a decisive role of early response competition to determine the success of multiple-choice action selection.

Selective effects of exercise on reactive and proactive inhibition in Parkinson's disease.

Objective: Patients with Parkinson's disease (PD) have an obvious motor inhibition disorder, which is closely related to their motor symptoms. Although previous studies have shown that exercise can improve their inhibition deficits, the effect of exercise on different types of inhibition (proactive and reactive inhibition) has not been addressed. Methods: We used a behavioral paradigm combined with a series of questionnaires to explore the effect of long-term exercise on different types of motor inhibition in 59 patients with PD aged 55-75 years. According to the intensity and frequency of exercise, the participants were divided into regular-exercise and no-exercise groups. To obtain the average reference value for inhibition ability at the same age, we also recruited 30 healthy elderly people as controls. Results: The main defect in the motor inhibition of PD is reactive inhibition, while proactive inhibition has no obvious differences compared with healthy controls. Additionally, compared with the non-exercise group, PD in the exercise group showed significantly better reaction speeds and reactive control ability, fewer motor symptoms and negative emotions. Conclusions: Taken together, the motor inhibition defects of patients with PD affect only reactive inhibition. In addition, PD with exercise reported fewer negative emotions than that of the non-exercise group, indicating that exercise can relieve negative emotions and improve behavioral symptoms and quality of life in PD to a certain extent. We demonstrate for the first time that exercise has and can improve reactive inhibition in PD patients and has no effect on proactive inhibition.

The superior response speed of table tennis players is associated with proactive inhibitory control.

Objective: To explore the mechanism behind the faster volitional reaction time (RT) of open skill sports athletes from the perspective of proactive inhibitory control, with the hypothesis that the superior response speed of athletes from open skill sports is related to their enhanced capacity for releasing inhibition. Methods: Participants were divided into two groups, an experimental group of 27 table tennis players and a control group of 27 non-athletes. By manipulating cue-target onset asynchrony (CTOA) in a simple cue-target detection task, the timing of target presentation occurred in different phases of the disinhibition process. The time needed for disinhibition were compared between groups. Results: For the experimental group, RT varied with CTOA at delays less than 200 ms; for CTOAs greater than 200 ms, RTs were not significantly different. For the control group, RT varied with CTOA for delays as long as 300 ms. Conclusions: Table tennis players took less time (200 ms) than non-athletes (300 ms) to complete the disinhibition process, which might partly explain their rapid response speed measured in unpredictable contexts. Significance: The study provided evidence for disinhibition speed as a new index to assess the capacity of proactive inhibitory control, and provided a new perspective to explore the superior RT of athletes from open skill sports. We also offered support for the fundamental cognitive benefits of table tennis training.

Proactive inhibition is marked by differences in the pattern of motor cortex activity during movement preparation and execution.

Successful human behavior relies on the ability to flexibly alter movements depending on the context in which they are made. One such context-dependent modulation is proactive inhibition, a type of behavioral inhibition used when anticipating the need to stop or change movements. We investigated how the motor cortex might prepare and execute movements made under different contexts. We used transcranial magnetic stimulation (TMS) in different coil orientations [postero-anterior (PA) and antero-posterior (AP) flowing currents] and pulse widths (120 and 30 µs) to probe the excitability of different inputs to corticospinal neurons while participants performed two reaction time tasks: a simple reaction time task and a stop-signal task requiring proactive inhibition. We took inspiration from state space models to assess whether the pattern of motor cortex activity changed due to proactive inhibition (PA and AP neuronal circuits represent the x and y axes of a state space upon which motor cortex activity unfolds during motor preparation and execution). We found that the rise in motor cortex excitability was delayed when proactive inhibition was required. State space visualizations showed altered patterns of motor cortex activity (combined PA120 and AP30 activity) during proactive inhibition, despite adjusting for reaction time. Overall, we show that the pattern of neural activity generated by the motor cortex during movement preparation and execution is dependent upon the context under which the movement is to be made.NEW & NOTEWORTHY Using directional TMS, we find that the human motor cortex flexibly changes its pattern of neural activity depending on the context in which a movement is due to be made. Interestingly, this occurs despite adjusting for reaction time. We also show that state space and dynamical systems models of movement can be noninvasively visualized in humans using TMS, thereby offering a novel method to study these powerful models in humans.

Memory and Proactive Interference for spatially distributed items.

Our ability to briefly retain information is often limited. Proactive Interference (PI) might contribute to these limitations (e.g., when items in recognition tests are difficult to reject after having appeared recently). In visual Working Memory (WM), spatial information might protect WM against PI, especially if encoding items together with their spatial locations makes item-location combinations less confusable than simple items without a spatial component. Here, I ask (1) if PI is observed for spatially distributed items, (2) if it arises among simple items or among item-location combinations, and (3) if spatial information affects PI at all. I show that, contrary to views that spatial information protects against PI, PI is reliably observed for spatially distributed items except when it is weak. PI mostly reflects items that appear recently or frequently as memory items, while occurrences as test items play a smaller role, presumably because their temporal context is easier to encode. Through mathematical modeling, I then show that interference occurs among simple items rather than item-location combinations. Finally, to understand the effects of spatial information, I separate the effects of (a) the presence and (b) the predictiveness of spatial information on memory and its susceptibility to PI. Memory is impaired when items are spatially distributed, but, depending on the analysis, unaffected by the predictiveness of spatial information. In contrast, the susceptibility to PI is unaffected by either manipulation. Visual memory is thus impaired by PI for spatially distributed items due to interference from recent memory items (rather than test items or item-location combinations).

Magnitude and sources of proactive interference in visual memory.

Proactive interference - the disruptive effect of old memories on new learning - is a long-established forgetting mechanism, yet there are doubts about its impact on visual working memory and uncertainty about the kinds of information that cause proactive interference. The present study aimed to assess these issues in three experiments using a modified recent probes task. Participants encoded four target images on each trial and determined whether a probe matched one of those targets. In Experiment 1, probes matching targets from trial N-1 or N-3 damaged responding in relation to a novel probe. Proactive interference was also produced by probes differing in state to a previously experienced target. This was further assessed in Experiments 2 and 3. Here, probes differing in colour to a previous target, or matching the general target category only, produced little proactive interference. Conversely, probes directly matching a prior target, or differing in state information, hindered task performance. This study found robust proactive interference in visual working memory that could endure over multiple trials, but it was also produced by stimuli closely resembling an old target. This challenges the notion that proactive interference is produced by an exact representation of a previously encoded image.

Does testing enhance new learning because it insulates against proactive interference?

Taking a test on previously learned material can enhance new learning. One explanation for this forward testing effect is that retrieval inoculates learners from proactive interference (PI). Although this release-from-PI account has received considerable empirical support, most extant evidence is correlational rather than causal. We tested this account by manipulating the level of PI that participants experience as they studied several lists while receiving interpolated tests or not. In Experiments 1 and 2, we found that testing benefited new learning similarly regardless of PI level. These results contradict those from Nunes and Weinstein (Memory, 20(2), 138-154, 2012), who found no forward testing effect when encoding conditions minimized PI. In Experiments 3 and 4, we failed to replicate their results. Together, our data indicate that reduced PI might be a byproduct, rather than a causal factor, of the forward testing effect.

Compromised reactive but intact proactive inhibitory motor control in Tourette disorder.

Tourette disorder (TD) is characterized by tics, which are sudden repetitive involuntary movements or vocalizations. Deficits in inhibitory control in TD patients remain inconclusive from the traditional method of estimating the ability to stop an impending action, which requires careful interpretation of a metric derived from race model. One possible explanation for these inconsistencies is that race model's assumptions of independent and stochastic rise of GO and STOP process to a fixed threshold are often violated, making the classical metric to assess inhibitory control less robust. Here, we used a pair of metrics derived from a recent alternative model to address why stopping performance in TD is unaffected despite atypical neural circuitry. These new metrics distinguish between proactive and reactive inhibitory control and estimate them separately. When these metrics in adult TD group were contrasted with healthy controls (HC), we identified robust deficits in reactive control, but not in proactive control in TD. The TD group exhibited difficulty in slowing down the speed of movement preparation, which they rectified by their intact ability to postpone the movement.

The influence of long-term memory on working memory: Age-differences in proactive facilitation and interference.

Prior learning can hinder subsequent memory, especially when there is conflict between old and new information. The ability to handle this proactive interference is an important source of differences in memory performance between younger and older adults. In younger participants, Oberauer et al. (2017, Journal of Experimental Psychology: Learning, Memory, and Cognition, 43[1], 1) report evidence of proactive facilitation from previously learned information in a working memory task in the absence of proactive interference between long-term and working memory. In the present work, we examine the generality of these findings to different stimulus materials and to older adults. Participants first learned image-word associations and then completed an image-word working memory task. Some pairs were the same as those initially learned, for which we expected facilitation relative to previously unencountered pairs. Other pairs were made up of previously learned elements in different combinations, for which we might expect interference. Younger and older participants showed similar levels of facilitation from previously learned associations relative to new pairs. In addition, older participants exhibited proactive interference from long-term to working memory, whereas younger participants exhibited facilitation, even for pairings that conflicted with those learned earlier in the experiment. These findings confirm older adults' greater susceptibility to proactive interference and we discuss the theoretical implications of younger adults' apparent immunity to interference.

Individual differences in proactive interference in rats (Rattus Norvegicus).

Individual differences in behaviors are seen across many species, and investigations have focused on traits linked to aggression, risk taking, emotionality, coping styles, and differences in cognitive systems. The current study investigated whether there were individual differences in proactive interference tasks in rats (Rattus Norvegicus), and tested hypotheses suggesting that these tasks should load onto a single factor and there should be clusters of rats who perform well or poorly on these tasks. The performance of 39 rats was tested across three learning tasks that all involved disengagement from an irrelevant previously learned stimulus to a relevant stimulus: latent inhibition (LI), partial reinforcement extinction effect (PREE), and reversal learning (RL). An exploratory factor analysis revealed the existence of one factor underlying performance. A cluster analysis revealed the existence of sets of rats displaying either weak LI and strong PREE and RL effects, or vice versa. These findings suggest that proactive interference may be based on a single underlying psychological system in rats.

Is there proactive inhibitory control during bilingual and bidialectal language production?

The bilingual language control literature generally assumes that cross-language interference resolution relies on inhibition of the non-target language. A similar approach has been taken in the bidialectal language control literature. However, there is little evidence along these lines for proactive language control, which entails a control process that is implemented as an anticipation of any cross-language interference. To further investigate the possibility of proactive inhibitory control, we examined the effect of language variety preparation time, by manipulating the cue-to-stimulus interval, on parallel language activation, by manipulating cognate status. If proactive language control relies on inhibition, one would expect less parallel language activation (i.e., a smaller cognate facilitation effect) with increased proactive inhibitory control (i.e., a long cue-to-stimulus interval). This was not the case with either bilinguals or bidialectals. So, the current study does not provide evidence for proactive inhibitory control during bilingual and bidialectal language production.

Effects of motor restrictions on preparatory brain activity.

Modifying established motor skills is a challenging endeavor due to proactive interference from undesired old to desired new actions, calling for high levels of cognitive control. Motor restrictions may facilitate the modification of motor skills by rendering undesired responses physically impossible, thus reducing demands to response inhibition. Here we studied behavioral and EEG effects of rule changes to typing in skilled touch-typists. The respective rule change-typing without using the left index finger-was either implemented per instruction only or with an additional motor restriction. In both groups, the rule change elicited delays and more errors in typing, indicating the occurrence of proactive interference. While stimulus-locked ERPs did not exhibit prominent effects of rule change or group, response-locked ERPs revealed that the time courses of preparatory brain activity preceding typing responses depended on the presence of motor restriction. Although further research is necessary to corroborate our findings, they indicate a novel brain correlate that represents changes in inhibitory response preparation induced by short-term motor restrictions.

Adjustments to Proactive Motor Inhibition without Effector-Specific Foreknowledge Are Reflected in a Bilateral Upregulation of Sensorimotor ß-Burst Rates.

Classic work using the stop-signal task has shown that humans can use inhibitory control to cancel already initiated movements. Subsequent work revealed that inhibitory control can be proactively recruited in anticipation of a potential stop-signal, thereby increasing the likelihood of successful movement cancellation. However, the exact neurophysiological effects of proactive inhibitory control on the motor system are still unclear. On the basis of classic views of sensorimotor ß-band activity, as well as recent findings demonstrating the burst-like nature of this signal, we recently proposed that proactive inhibitory control is implemented by influencing the rate of sensorimotor ß-bursts during movement initiation. Here, we directly tested this hypothesis using scalp EEG recordings of ß-band activity in 41 healthy human adults during a bimanual RT task. By comparing motor responses made in two different contexts-during blocks with or without stop-signals-we found that premovement ß-burst rates over both contralateral and ipsilateral sensorimotor areas were increased in stop-signal blocks compared to pure-go blocks. Moreover, the degree of this burst rate difference indexed the behavioral implementation of proactive inhibition (i.e., the degree of anticipatory response slowing in the stop-signal blocks). Finally, exploratory analyses showed that these condition differences were explained by a significant increase in ß bursting that was already present during baseline period before the movement initiation signal. Together, this suggests that the strategic deployment of proactive inhibitory motor control is implemented by upregulating the tonic inhibition of the motor system, signified by increased sensorimotor ß-bursting both before and after signals to initiate a movement.

Intact Proactive Motor Inhibition after Unilateral Prefrontal Cortex or Basal Ganglia Lesions.

Previous research provided evidence for the critical importance of the PFC and BG for reactive motor inhibition, that is, when actions are cancelled in response to external signals. Less is known about the role of the PFC and BG in proactive motor inhibition, referring to preparation for an upcoming stop signal. In this study, patients with unilateral lesions to the BG or lateral PFC performed in a cued go/no-go task, whereas their EEG was recorded. The paradigm called for cue-based preparation for upcoming, lateralized no-go signals. Based on previous findings, we focused on EEG indices of cognitive control (prefrontal beta), motor preparation (sensorimotor mu/beta, contingent negative variation [CNV]), and preparatory attention (occipital alpha, CNV). On a behavioral level, no differences between patients and controls were found, suggesting an intact ability to proactively prepare for motor inhibition. Patients showed an altered preparatory CNV effect, but no other differences in electrophysiological activity related to proactive and reactive motor inhibition. Our results suggest a context-dependent role of BG and PFC structures in motor inhibition, being critical in reactive, unpredictable contexts, but less so in situations where one can prepare for stopping on a short timescale.